No pun intended in the title but I find it rather interesting that Tom has had some sort of major 'running' sequence in a lot of his films, especially the more recent ones.

Sprint sequences:
1. Ethan in downtown Shanghai after the Rabbit's Foot interrogation (M:I 3).
2. Ray and the first tripod he sees that starts to vaporize everything in its path (WotW).
3. Vincent chasing Max who took off with his briefcase (Collateral).
4. John Anderton on the run (MR).
5. David running through an empty Times Square (VS).

These are just a select few.

Another, perhaps more intriguing theme has to be the 'eyes' trilogy. Tom worked on three films all dealing with a character who couldn't see or was struggling to see the bigger picture.
Eyes Wide Shut. I'll admit, I didn't understand Kubrick's vision in this film but the title seems to refer to the character of Bill who was so naive that he couldn't actually understand the bigger implications of the small incidents that occurred around him.
Vanilla Sky. Everyone is telling David to 'open your eyes' and wake up. It's ironic. When David was alive he lived his life like a dream but when he finally 'woke up' to reality, Julie took his life and thrust it into a nightmare. I think his conscience must have played some part in messing up his lucid dream (not just technicalities) and he had trouble seeing that (he was in a lucid dream).
Minority Report. Can you see? A film dealing with the issue of pre-destiny vs free will, John tries to find out the meaning between Agatha's visions of Anne Lively. He believes in the system, a little too much faith perhaps as it blinds him to the fact that there is a very huge flaw in pre-crime. A human one.

In the land of the blind, the one-eyed man is king.